First-in-Class Treatment Approved for Hypertrophic Cardiomyopathy

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April 28, 2022 – Bristol Myers Squibb’s CamzyosTM (mavacamten) has been approved to improve functional capacity and symptoms as a treatment for symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM) in adults. Camzyos is the first drug in its class to receive FDA approval for this indication.

  • Obstructive HCM occurs when a wall of muscle in the heart becomes thicker than normal and interferes with blood flow. Usually, the condition is caused by genetic mutations.
  • Due to a risk of heart failure, Camzyos dosing must be individualized based on the patient’s clinical status and echocardiographic assessments of treatment response. The medication is taken once daily by mouth.
  • Camzyos has launched at an annual wholesale acquisition cost (WAC) of $89,500.