Skyrizi Granted New Indication for Crohn’s Disease

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June 17, 2022 – Skyrizi® (risankizumab-rzaa – AbbVie) is now the first and only specific interleukin-23 (IL-23) inhibitor to receive FDA approval for treating moderately to severely active Crohn's disease in adults.

  • First FDA approved in 2019, Skyrizi is also indicated to treat active psoriatic arthritis and moderate to severe plaque psoriasis.
  • The recommended starting dose for Crohn’s disease is 600mg administered by intravenous infusion at Weeks 0, 4, and 8 of treatment. Maintenance treatment begins at Week 12, with a recommended dose of 360mg administered by subcutaneous injection once every eight weeks.