March 29, 2023, the U.S. Food and Drug Administration approved Narcan, 4 milligram (mg) naloxone
hydrochloride nasal spray for over-the-counter (OTC), nonprescription use – the first naloxone product
approved for use without a prescription. Naloxone is a medication that rapidly reverses the effects of
opioid overdose and is the standard treatment for opioid overdose.